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Elbonix25mg-Eltrombopag-Pormacta

Product Name: Elbonix

Generic Name: Eltrombopag

Strength: 25mg

Volume: 28 tablets

Available strength: 25 and 50 mg

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Elbonix25mg-Eltrombopag-Pormacta Description:

Elbonix25mg-Eltrombopag-Pormacta: Eltrombopag also known as Promacta in the US and as Revolade outside the US is used to treat thrombocytopenia also known as abnormally low platelet count in the blood cells. It is also used to treat aplastic anemia.

This medicine is used to treat adults and children of one year of age who are affected by a blood disorder called  Idiopathic Thrombocytopenic Purpura(ITP). This medicine is used after Splenectomy (Surgery to remove the spleen) and other medicines like steroids, immunoglobulin has not worked well enough.

It is also used to treat thrombocytopenia in patients with chronic hepatitis C along with interferon treatment. Eltrombopag works by stimulating bone marrow to produce small platelets and that helps blood clotting for patients with thrombocytopenia.

Elbonix25mg-Eltrombopag-Pormacta Indication:

Eltrombopag is a medication used to treat ITP, thrombocytopenia in chronic hepatitis C patients, and severe aplastic anemia, which is caused by immune system destruction of platelets.

Mechanism of Action:

Eltrombopag is a medication that helps increase platelet production in individuals with thrombocytopenia. It binds to and activates a protein called the TPO receptor found on large bone marrow cells called megakaryocytes that produce platelets. This activation triggers a signaling cascade that leads to the growth and differentiation of megakaryocytes, resulting in increased platelet production. Additionally, eltrombopag can improve platelet survival and reduce destruction by the immune system. Compared to other TPO receptor agonists, eltrombopag is a small molecule drug that can easily enter the bone marrow, making it highly effective in increasing platelet counts. Overall, eltrombopag is a powerful and effective treatment for thrombocytopenia in various conditions.

Dosage and Absorption:

Dosage:

Eltrombopag’s starting dose is 50 mg daily, with adjustments for East Asian ancestry, hepatic impairment, and children aged 1-5 years. Maximum dose is 75 mg.

Absorption:

Eltrombopag, an oral medication, is rapidly absorbed, reaching maximum plasma concentration within 1.35 to 2.5 hours, with an estimated 89% oral bioavailability.

Tips for taking eltrombopag:

  • Take eltrombopag at the same time each day.
  • Eltrombopag can be taken with or without food.
  • If you miss a dose of eltrombopag, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed dose.
  • If you have any questions about taking eltrombopag, talk to your doctor or pharmacist.

Elbonix25mg-Eltrombopag-Pormacta Side Effects:

Eltrombopag’s mild side effects include headache, dizziness, diarrhea, fatigue, nausea, vomiting, and abdominal pain. Less common include liver problems, decreased white blood cell count, increased thrombosis risk, vision changes, shortness of breath, chest pain, and severe allergic reactions.

Eltrombopag Olamine:

To help with thrombocytopenia in both adults and children with chronic immune thrombocytopenia, chronic hepatitis C patients, and severe aplastic anemia, Eltrombopag olamine is prescribed. This medication is a thrombopoietin (TPO) receptor agonist, which means it can enter the bone marrow more easily than other drugs in this class, making it an effective option for increasing platelet counts. Patients take it orally once a day, and their dosage is adjusted based on their platelet count and response to treatment. While common side effects include headache, dizziness, diarrhea, fatigue, nausea, and vomiting, less common side effects include liver problems, decreased white blood cell count, decreased neutrophil count, and increased risk of thrombosis. Eltrombopag olamine is safe and effective for treating thrombocytopenia, but it is important to consult a doctor about the risks and benefits before beginning treatment.

Eltrombopag Cirrhosis:

If you have cirrhosis and are experiencing thrombocytopenia (a common bleeding complication), your doctor may suggest using eltrombopag. This medication is a thrombopoietin (TPO) receptor agonist, which helps to boost platelet production in the bone marrow, leading to higher platelet counts. It’s important to note, however, that eltrombopag can also increase your risk of blood clots, particularly if you have cirrhosis. As such, before starting treatment, it’s crucial to carefully consider the potential risks and benefits of this medication. You should consult with your doctor about your situation and closely monitor your platelet count throughout your treatment.

Aplastic Anemia Eltrombopag:

The most common symptoms of aplastic anemia include:

  • Fatigue
  • Shortness of breath
  • Paleness
  • Easy bruising and bleeding
  • Increased risk of infection

Aplastic anemia is caused by several factors, including:

  • Autoimmune disorders: The immune system attacks and destroys the stem cells in the bone marrow.
  • Inherited gene mutations: Some people are born with gene mutations that make them more likely to develop aplastic anemia.
  • Exposure to certain chemicals or drugs: Some chemicals and drugs, such as chemotherapy drugs and antibiotics, can damage the stem cells in the bone marrow.
  • Viral infections: Certain viruses, such as hepatitis and Epstein-Barr virus, can trigger aplastic anemia.

In some cases, the cause of aplastic anemia is unknown.

There is no cure for aplastic anemia, but there are treatments that can help manage the symptoms and improve the quality of life. Treatment options include:

  • Blood transfusions: Blood transfusions can help replenish the supply of red blood cells, white blood cells, and platelets.
  • Immune system suppressants: Immune system suppressants can help stop the immune system from attacking the stem cells in the bone marrow.
  • Stem cell transplantation: A stem cell transplant is a procedure in which healthy stem cells are transplanted into the bone marrow. Stem cell transplants are the only curative treatment for aplastic anemia. (8)

ATG Cyclosporine Eltrombopag:

ATG and cyclosporine are commonly used to treat aplastic anemia, a serious blood disorder where the bone marrow doesn’t produce enough blood cells. ATG targets and destroys T cells, which are believed to contribute to the condition. Cyclosporine suppresses the immune system, preventing the immune system from attacking bone marrow stem cells. The combination is effective in treating up to 80% of patients but can cause side effects like fever, chills, rash, and kidney damage.

Avalet 20mg vs Elbonix25/50mg

Avalet 20mg and Elbonix-25mg are tablet formulations of eltrombopag olamine, used to treat thrombocytopenia in chronic immune thrombocytopenia, chronic hepatitis C, and severe aplastic anemia. Avalet 20mg contains 20mg of eltrombopag olamine, while Elbonix-25mg contains 25mg. Both are generally safe and effective but can cause side effects like headache, dizziness, diarrhea, fatigue, nausea, and vomiting. Consult a doctor about treatment risks and closely monitor platelet count.

Similarity Between Ebonix and Elopag

Elbonix and Elopag are thrombopoietin receptor agonists used to treat thrombocytopenia in adults and children with chronic immune thrombocytopenia, chronic hepatitis C, and severe aplastic anemia. Both medications are safe and effective but can cause side effects like headache, dizziness, diarrhea, fatigue, nausea, and vomiting. It is crucial to consult a doctor about the risks and benefits of treatment and closely monitor platelet count while taking either medication.

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How does Elbonix25mg-Eltrombopag-Pormacta works?
If you have lower platelet count due to persistent or chronic ITP, and then you start treating with a steroid that may stop working and then at this stage, Eltrombopag can work differently than steroid or IVIg. This way Eltrombopag boosts platelet in a patient's body and helps in blood clotting.
Elbonix25mg-Eltrombopag-Pormacta
Eltrombopag mimics the motion of thrombopoietin by binding to the thrombopoietin receptor and activating signaling pathways inside megakaryocytes. This results in multiplied proliferation and differentiation of megakaryocytes, ensuing in the production of more platelets. As a result, the platelet depend in the bloodstream rises, which facilitates to the prevention of bleeding episodes and management of the underlying situations associated with low platelet counts.
How does Elbonix25mg-Eltrombopag-Pormacta work?
The drug works using binding to and activating the thrombopoietin receptor, that's positioned on the floor of cells called megakaryocytes in the bone marrow. Thrombopoietin is an herbal hormone that regulates platelet production. With the aid of activating the thrombopoietin receptor, eltrombopag initiates a sequence of cell signaling events that sell the increase and differentiation of megakaryocytes. As a result, greater megakaryocytes are formed and they produce greater platelets, which can be then launched into the bloodstream. This growth in platelet remember enables to prevent bleeding episodes and manipulate conditions related to low platelet levels, consisting of idiopathic thrombocytopenic purpura (ITP) and persistent hepatitis C-related thrombocytopenia.
What is Elbonix25mg-Eltrombopag-Pormacta used for?
Eltrombopag is used to treat positive medical conditions characterized through low platelet counts inside the blood. It is commonly prescribed for the subsequent situations: Idiopathic Thrombocytopenic Purpura (ITP): ITP is an autoimmune disease wherein the immune device mistakenly attacks and destroys platelets, leading to a low platelet remember. Eltrombopag enables to rise of platelet stages inside the blood and decreases the hazard of bleeding in patients with ITP. Persistent Hepatitis C-associated Thrombocytopenia: some sufferers with persistent hepatitis C infection might also expand low platelet counts due to the virus affecting the bone marrow's ability to produce platelets. Eltrombopag can be utilized in those cases to boost platelet ranges and manipulate thrombocytopenia. Severe Aplastic Anemia: In rare instances, eltrombopag may be used in combination with different remedies to assist in increasing platelet counts in sufferers with severe aplastic anemia, a condition where the bone marrow fails to provide enough blood cells, along with platelets.

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