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Palbonix100mg|125mg-Palbociclib

Product Name: Palbonix

Generic Name: Palbocicilib

Strength: 125mg

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Summary of the Products’ Characteristics (SPC): Palbonix100mg|125mg-Palbociclib

Palbonix100mg|125mg-Palbocicl Description:

Palbonix100mg|125mg-Palbociclib (brand name of Palbociclib- Ibrance) is a medication prescribed to treat advanced breast cancer or metastatic breast cancer for patients who test positive for hormone receptors but negative for HER2. Palbociclib is taken orally once a day and works by inhibiting CDK4 and CDK6, proteins that play a significant role in cell growth and division. When CDK4 and CDK6 activity is increased in cancer cells, it can lead to uncontrolled multiplication. By blocking these proteins, Palbociclib slows down the growth of cancer cells in HR-positive breast cancer patients. Usually, Palbociclib is taken along with other hormonal therapies like aromatase inhibitors or fulvestrants. It is often used as a first-line treatment for women with HR-positive, HER2-negative advanced or metastatic breast cancer. Patients who have already undergone other hormonal treatments can also use Palbociclib if their disease progresses.[1]

Palbonix100mg|125mg-Palbociclib Indication:

Palbociclib (brand name Ibrance) is a medication prescribed to treat advanced or metastatic breast cancer that is hormone receptor (HR)-positive and HER2-negative. It is an oral medication that is taken once daily. Palbociclib functions as a cyclin-dependent kinase (CDK) 4 and 6 inhibitor. CDK4 and 6 are proteins that are vital to cell growth and division. In some cancers, including HR-positive breast cancer, the activity of CDK4 and 6 is elevated, which leads to the uncontrollable multiplication of cancer cells. Palbociclib slows the growth of HR-positive breast cancer cells by blocking CDK4 and 6. Palbociclib is normally used together with other hormonal therapies, such as aromatase inhibitors or fulvestrant. It can be used as the first treatment for women with HR-positive, HER2-negative advanced, or metastatic breast cancer, or it can be used for patients who have disease progression after undergoing other hormonal treatments. Overall, Palbociclib is an effective medication for treating HR-positive, HER2-negative advanced, or metastatic breast cancer when used as directed by a healthcare professional. [2]

Palbociclib is indicated for the treatment of the following:

  • HR-positive, HER2-negative advanced or metastatic breast cancer in combination with an aromatase inhibitor as initial endocrine-based therapy for postmenopausal women or in men
  • HR-positive, HER2-negative advanced or metastatic breast cancer following disease progression on or after endocrine therapy for postmenopausal women or in men

Mechanism of Action:

Did you know that Palbonix100mg|125mg-Palbociclib is a drug that selectively inhibits cyclin-dependent kinases 4 and 6 (CDK4/6)? These kinases are essential for cell growth and division. Palbociclib works by binding to the ATP pocket of CDK4 and 6, which prevents their activation and binding. As a result, the retinoblastoma protein (Rb), which is a tumor suppressor protein, is not phosphorylated. This leads to cell cycle arrest and ultimately cell death. Palbociclib is particularly effective in treating breast cancer cells that are HR-positive. It works best when combined with other hormonal therapies, improving progression-free survival and overall survival rates in HR-positive patients.[3]

Side Effects of  Palbonix100mg|125mg-Palbociclib:

Palbonix100mg|125mg-Palbociclib is a medication that can cause various side effects, including fatigue, neutropenia, leukopenia, thrombocytopenia, diarrhea, nausea, vomiting, hair loss, mouth sores, and decreased appetite. Other less common side effects include interstitial lung disease, liver damage, rash, itching, dry skin, headache, constipation, muscle pain, joint pain, sweating, decreased sex drive, vaginal dryness, hot flashes, and night sweats. Serious side effects include heart failure, myelosuppression, severe infection, and severe bleeding.[4]

Life Expectancy of Palbonix100mg|125mg:

Palbonix100mg|125mg-Palbociclib treatment has been shown to improve the life expectancy of patients with hormone receptor-positive, HER2-negative advanced or metastatic breast cancer. A clinical trial found that palbociclib combined with letrozole and fulvestrant improved median overall survival from 24.8 months to 37.2 months in patients who had progressed on prior endocrine therapy. However, the actual life expectancy for each patient will vary based on factors such as cancer stage, overall health, and treatment response. These studies highlight the potential benefits of palbociclib in improving overall survival.[5]

Palbociclib Cost/Price | Ibrance Cost:

The cost of palbociclib (Ibrance) varies depending on several factors, including the dose, the number of capsules, and the pharmacy where you purchase it. In the United States, the cash price for a 21-day supply of palbociclib 125 mg capsules is around $13,000 to $13,500. However, most people do not pay this price. But we are providing palbociclib at a very low price. Please contact us to know the actual price of Palbonix 125/150. We promise you the best price in the market. Palbociclib price in India is lower than another country than the USA and Europe. It costs  1/5th of the USA price. To know the exact price though it varies from time to time contact us.

Palbonix100mg|125mg-Palbociclib for Breast Cancer

Palbociclib is a medication that effectively treats breast cancer and metastatic breast cancer. It can be used either alone or in combination with other medications. This particular medication is classified as a CDK4/6 inhibitor, which means it works by hindering the activity of CDK4 and CDK6 proteins that are responsible for the growth and division of cancer cells. By blocking these proteins, palbociclib can slow down the growth of cancer cells and reduce the size of tumors.
The FDA has approved Palbociclib for the treatment of :

  • advanced or metastatic hormone receptor-positive, HER2-negative breast cancer. Fulvestrant, letrozole, or an aromatase inhibitor can be used in combination with palbociclib to treat postmenopausal women with breast cancer, depending on their treatment history.
  • Furthermore, Palbociclib is undergoing clinical trials for the treatment of other types of cancer, such as lung cancer and prostate cancer.

Abemaciclib vs Palbociclib vs Ribociclib

Feature Abemaciclib Palbociclib Ribociclib
Chemical class Cyclin-dependent kinase (CDK) 4/6 inhibitor Cyclin-dependent kinase (CDK) 4/6 inhibitor Cyclin-dependent kinase (CDK) 4/6 inhibitor
Brand name Verzenio Ibrance Kisqali
Dosing schedule Twice daily Once daily Once daily
Time to peak plasma concentration 4-8 hours 6-12 hours 4-6 hours
Half-life 16-24 hours 29 hours 24-32 hours
Metabolism CYP3A4 CYP3A4 CYP3A4
Common side effects Neutropenia, leukopenia, lymphopenia, anemia, thrombocytopenia, fatigue, nausea, vomiting, diarrhea, constipation, hair loss, rash, muscle pain, joint pain, mouth sores, loss of appetite, taste changes, difficulty sleeping, headache, dizziness, fever Neutropenia, leukopenia, lymphopenia, anemia, thrombocytopenia, fatigue, nausea, vomiting, diarrhea, constipation, hair loss, rash, muscle pain, joint pain, mouth sores, loss of appetite, taste changes, difficulty sleeping, headache, dizziness, fever Neutropenia, leukopenia, lymphopenia, anemia, thrombocytopenia, fatigue, nausea, vomiting, diarrhea, constipation, hair loss, rash, muscle pain, joint pain, mouth sores, loss of appetite, taste changes, difficulty sleeping, headache, dizziness, fever
Approved indications Advanced or metastatic hormone receptor-positive, HER2-negative breast cancer in combination with fulvestrant in postmenopausal women Advanced or metastatic hormone receptor-positive, HER2-negative breast cancer in combination with fulvestrant in postmenopausal women Advanced or metastatic hormone receptor-positive, HER2-negative breast cancer in combination with fulvestrant in postmenopausal women

Abemaciclib binds to plasma proteins more tightly and has a shorter half-life than the other two medications, making it less likely to enter certain tissues like the brain. All three drugs have shown efficacy in slowing breast cancer tumor growth and prolonging progression-free survival. However, Some studies suggest that Abemaciclib may improve progression-free survival, but more research is needed to confirm this. The best choice of CDK4/6 inhibitor for a patient depends on their tumor characteristics, other medical conditions, and personal preferences.

Plabociclib Package insert

Each Palbonix 125mg box contains 21 tablets, a user manual with possible guidelines and precautions.

Frequently Asked Questions About Palbonix Palbociclib 125 mg


Q: What is Palbociclib?

Palbociclib is a medication prescribed to treat advanced breast cancer or metastatic breast cancer for patients who test positive for hormone receptors but negative for HER2. Palbociclib is taken orally once a day and works by inhibiting CDK4 and CDK6, proteins that play a significant role in cell growth and division. When CDK4 and CDK6 activity is increased in cancer cells, it can lead to uncontrolled multiplication. By blocking these proteins, Palbociclib slows down the growth of cancer cells in HR-positive breast cancer patients. Usually, Palbociclib is taken along with other hormonal therapies like aromatase inhibitors or fulvestrants. It is often used as a first-line treatment for women with HR-positive, HER2-negative advanced or metastatic breast cancer. Patients who have already undergone other hormonal treatments can also use Palbociclib if their disease progresses.

Q: How does Palbociclib work?

Did you know that Palbonix100mg|125mg-Palbociclib is a drug that selectively inhibits cyclin-dependent kinases 4 and 6 (CDK4/6)? These kinases are essential for cell growth and division. Palbociclib works by binding to the ATP pocket of CDK4 and 6, which prevents their activation and binding. As a result, the retinoblastoma protein (Rb), which is a tumor suppressor protein, is not phosphorylated. This leads to cell cycle arrest and ultimately cell death. Palbociclib is particularly effective in treating breast cancer cells that are HR-positive. It works best when combined with other hormonal therapies, improving progression-free survival and overall survival rates in HR-positive patients.

Q: How much does Palbociclib cost?

The cost of palbociclib (Ibrance) varies depending on several factors, including the dose, the number of capsules, and the pharmacy where you purchase it. In the United States, the cash price for a 21-day supply of palbociclib 125 mg capsules is around $13,000 to $13,500. However, most people do not pay this price. But we are providing palbociclib at a very low price. Please contact us to know the actual price of Palbonix 125/150. We promise you the best price in the market. Palbociclib price in India is lower than another country than the USA and Europe. It costs 1/5th of the USA price. To know the exact price though it varies from time to time contact us.

Q: Is Palbociclib Chemotherapy?

Palbociclib is a targeted therapy drug used to treat hormone receptor-positive, HER2-negative breast cancer. It targets specific molecules involved in cancer cell growth and survival, reducing the risk of damaging healthy cells. It works by blocking the activity of CDK4 and CDK6 proteins, slowing cancer cell growth and shrinking tumors. Although it is safe and effective, side effects like neutropenia, leukopenia, lymphopenia, anemia, and thrombocytopenia are usually manageable.

Q: What happens if I miss a dose of Palbonix?

If you miss a palbociclib dose or are sick (vomit) soon after taking it, do not take an extra dose to make up for the one you missed. Keep to your usual amount and speak to someone in your treatment team.

Overdose: Monitor the patient for evidence of toxicity if an overdose occurs. Treatment of overdose includes monitoring of vital signs as well as observation of the clinical status of the patient.

 

Storage: Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

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