304 North Cardinal St.
Dorchester Center, MA 02124
Product Name: Lorbrexen
Brand Name: Lorbrena
Generic Name: Loraltinib
Quantity: 30 Tablets
Lorbrexen-100-lorlatinib is a non-small-lung cancer medicine that has huge potential against most known resistance mutations that can develop during treatment with crizotinib and second-generation ALK TKIs.
Lorbrexen, manufactured by Everest Pharmaceuticals Ltd in Bangladesh, is equally effective as Loraltinib.
Lorlatinib is prescribed to adult patients who have Anaplastic Lymphoma Kinase metastatic non-small cell lung cancer. (1) It is also recommended for those who haveadvanced NSCLC and have not previously received ALK inhibitor treatment, and those whose disease has not been cured after using Alectinib, Ceritinib, or Crizotinib.
Lorlatinib is a third-generation anaplastic lymphoma kinase (ALK) inhibitor, used to treat non-small cell lung cancer (NSCLC) with ALK mutations, including those that have become resistant to other ALK inhibitors. It is also used to treat ROS1-positive NSCLC.
Lorlatinib works by blocking the ALK and ROS1 proteins. These proteins are involved in the growth and survival of cancer cells. By blocking these proteins, lorlatinib can help slow or stop cancer cell growth.
Lorlatinib is a reversible inhibitor, which means that it can bind to and unbind from the ALK and ROS1 proteins. This allows lorlatinib to be more effective against tumors that have developed resistance to other ALK inhibitors.
Here is a simplified explanation of how lorlatinib works:
After being taken orally, Lorlatinib is quickly absorbed and reaches its peak concentration in the bloodstream within 1-2 hours. It has high bioavailability, meaning that a significant amount of the drug is absorbed into the bloodstream.
The recommended daily dosage of Lorlatinib is 100 mg, which can be taken with or without food. However, if a patient has difficulty tolerating this amount, a reduced dosage of either 75 mg or 50 mg can be administered.
It’s important to avoid taking Lorlatinib with strong CYP3A inhibitors such as ketoconazole, itraconazole, or posaconazole, which can increase blood levels and cause side effects. Additionally, caution should be used when administering the drug to patients with liver or kidney problems, as they may require a lower dosage.
It’s essential to understand that the dosage and administration of Lorlatinib vary depending on individual patient needs and medical history. Therefore, it’s crucial to consult with a doctor to determine the appropriate dosage for each patient. (3)
The most common side effects of lorlatinib are mild and go away on their own. These side effects may include:
Less common side effects of lorlatinib include:
Serious side effects of lorlatinib are rare. However, it is important to be aware of the potential side effects of lorlatinib so that you can talk to your doctor if you experience any of them.
If you are taking lorlatinib, be sure to tell your doctor about any other medications you are taking, including over-the-counter medications, herbal supplements, and vitamins. Some medications can interact with lorlatinib and cause side effects.
You should also tell your doctor about any medical conditions you have, including liver problems, kidney problems, heart problems, and nerve problems. Lorlatinib may not be safe for everyone to take. (4)
The median progression-free survival (PFS) was 9.9 months (with a 95% confidence interval of 6 to 12.3 months) from when lorlatinib was first given. The median overall survival (OS) from the start of lorlatinib treatment was 32.9 months (with a 95% confidence interval of 18.7 months to not reached). The median OS from the time of advanced non-small cell lung cancer (NSCLC) diagnosis was 97.3 months (with a 95% confidence interval of 75.7 to 152.8 months). (5)
Lorlatinib is a targeted therapy medication that is specifically designed to treat non-small cell lung cancer (NSCLC) in individuals who are ROS-1 positive. ROS-1 is a protein that plays a crucial role in the growth and survival of cancer cells, and lorlatinib works by blocking this protein. This can help to reduce tumor size and increase survival rates.
Although lorlatinib is a relatively new drug, it has already become a first-line treatment for those with ROS-1-positive NSCLC. It is also used to treat patients who have not responded well to other treatments for this type of cancer.
Overall, lorlatinib is generally well-tolerated, with mild side effects such as nausea, vomiting, diarrhea, fatigue, and decreased appetite. However, more serious side effects such as liver problems, lung problems, and heart problems are rare.
If you are considering lorlatinib as a treatment option for your ROS-1-positive NSCLC, it is important to discuss the potential risks and benefits with your doctor. While lorlatinib can be an effective treatment, it is crucial to be aware of the potential side effects. (6)
Comparison Among ALECTINIB vs LORALTINB vs CRIZOTINIB
Alectinib, lorlatinib, and crizotinib are all targeted therapy medications used to treat non-small cell lung cancer (NSCLC) with ALK mutations. They work by blocking the ALK protein, which is involved in the growth and survival of cancer cells.
Here is a comparison of the three medications:
|Generation||Second-generation ALK inhibitor||Third-generation ALK inhibitor||First-generation ALK inhibitor|
|Efficacy||Highly effective against ALK-positive NSCLC, including tumors that have become resistant to crizotinib||Very effective against ALK-positive NSCLC, including tumors that have become resistant to other ALK inhibitors||Effective against ALK-positive NSCLC, but not as effective as alectinib or lorlatinib|
|Side effects||Generally well-tolerated, with mild to moderate side effects||Generally well-tolerated, with mild to moderate side effects||More common and severe side effects than alectinib or lorlatinib|
|Cost||Expensive||Expensive||Less expensive than alectinib or lorlatinib|
The best medication for you will depend on your individual needs and medical history. If you have ALK-positive NSCLC, talk to your doctor about the risks and benefits of each medication to decide which one is right for you. (7)
What is Lorbrexen-100-lorlatinib?
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