Palboxen-125mg-Palbociclib | Buy Breast Cancer Medicine

Package Insert for Palboxen-100mg-Palbociclib

Description

Palboxen-125mg-Palbociclib is a prescription medicine used to treat certain type of breast cancer. It is used to treat certain type of breast cancer. Which is a selective cyclin dependent kinase (CDK4 and CDK6) inhibitor. These kinase are important for cell cycle growth.

By blocking those cell Palboxen stop the growth of cancer cells. Sometimes it is used in combination with other medications, such as an aromatase inhibitor to treat hormone receptor-positive. It is also used in women to treat advanced metastatic breast cancer, who have gone under menopause.

Indications

Palboxen is indicated to treat hormone receptor positive, human epidermal growth factor receptor-2 negative and, advanced or metastatic breast cancer. Although its specific indications depends on whether the patients have received endocrine therapy for their breast cancer.

• As initial endocrine based-therapy: It is used in combination with letrozole for postmenopausal women or man with HR-positive and HER2 negative.
• As prior endocrine based-therapy: It is also used in combination with Fulvestrant for women and man with HR-positive and HER2-negative.

You should know that it is not a standalone treatment. It is always should be used in combination with other medications as mentioned above. It is hard to say for a health care professional that it will be effective enough to improve patients health condition.

Mechanism of Action

Palboxen-100mg-Palbociclib is a targeted therapy belonging to the class of medication called cyclin dependent kinase inhibitors. It plays a crucial role in halting the growth and spread of certain types of breast cancers.

Here’s a breakdown of its mechanism of action:

1. Targeting CDK4/6:

• CDK4 and CDK6 are enzymes that drive cell cycle progression. They achieve this by partnering with cyclins, particularly cyclin D, to phosphorylate a protein called retinoblastoma protein (Rb).
• Palbociclib binds to the ATP-binding pocket of CDK4/6 and, preventing them from binding to ATP. Without ATP, CDK4/6 become inactive and unable to phosphorylate Rb.

2. Stopping Rb in its Tracks:

• Rb blocks cells from entering the S phase (DNA synthesis) of the cell cycle.
• By inhibiting CDK4/6 and keeping Rb unphosphorylated, palbociclib essentially puts the brakes on cell division, preventing cancer cells from replicating their DNA and multiplying uncontrollably.

Dosage and Administration

Dosage of palbociclib depends on patients and their medical condition. The recommended dose for most of the patient is 125 mg capsule or tablet taken orally once a day. Doctor or pharmacist suggest palbociclib considering following conditions.

• 21-day-on, 7-day-off cycle: This means taking the medication daily for 21 consecutive days followed by a 7-day break. This cycle is then repeated.
• Initial endocrine-based therapy,In combination with an aromatase inhibitor: 125 mg daily of palbociclib.
• Following disease progression with prior endocrine therapy, In combination with fulvestrant: 125 mg daily of palbociclib.
• When given with this drug, the recommended dose of fulvestrant is 500 mg on Days 1, 15, 29, and once monthly thereafter. Refer to the prescribing Information for fulvestrant.
• Pre perimenopausal women treated with the combination of this drug plus fulvestrant should be treated with luteinizing hormone-releasing hormone (LHRH) agonists according to local protocol.

Before Taking Palbociclib

If you are allergic to palbociclib you should not use this medicine. Please consult with your doctor if you have any liver or kidney disease. On the other hand palboxen may harm an unborn baby or it may cause birth defect if children’s father or mother take it.

In case of any urgency ask your doctor for medical advice. If you are a woman do not take this medicine during pregnancy. Take birth control protection while you are taking this medicine. Complete this course at least 3 weeks before pregnancy.

Side Effects

There are a few common side effects which can occur during taking this medicine. Such as nausea, vomiting, loss of appetite, diarrhea, tiredness, weakness, numbness, hair loss, mouth sores, tingling of arm legs. There are also some serious side effects like shortness of breath and other serious complications.

Cost of Palbociclib or Ibrance( Palboxen)

Anti-cancer drugs are very costly and sometimes out of budget. The ibrance cost couple thousands dollars. Where it is not possible to buy this medicine for every breast cancer patients.

Palbonix is produced in Bangladesh by everest pharma which is similarly effective as the generic one. To know the cost of this medicine please feel free to whats app us we are also available at we chat.

Frequently Asked Questions About Palboxen-125mg-Palbociclib

Q: How does Palboxen-125mg-Palbociclib Work?

Palboxen 125 mg works by blocking these proteins, helping to stop the cancer cells from growing and dividing. When combined with hormone therapies that block the effects of estrogen on cancer cells, palbociclib helps to delay the growth of ER+, HER2-negative breast cancer. for more information visit

Q: What happens if I miss a dose of Palboxen?

If you miss a palbociclib dose or are sick (vomit) soon after taking it, do not take an extra dose to make up for the one you missed. Keep to your usual amount and speak to someone in your treatment team.

Q: How many days should I take Ibrance?

In general you have to take ibrance for 21 days in a row with other medications like aromatase inhibitor or fulvestrant. The cycle is repeated in every 28 days as long as you can tolerate side effects from this medicine.

Q: What is Ibrance?

Ibrance is a cyclin dependent kinase inhibitor. Which inhibit CDK4 and CDK6. It is used to treat certain types of breast cancer such as HR-positive and HER2-negative.

Overdose: If an overdose occurs the patient must be monitored for evidence of toxicity. Treatment of overdose includes monitoring of vital signs as well as observation of the clinical status of the patient.

Storage: Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

To find more Breast Cancer medicine see the category.

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