Upacit XR (Generic Upadacitinib)

Upacit XR (generic Upadacitinib) is indicated to treat certain types of autoimmune disease, like rheumatoid arthritis, alopecia areata. Other than these, it is also indicated to treat the following conditions in adults

• for moderate to severe rheumatoid arthritis treatment.
• psoriatic arthritis in autoimmune disease.
• ankylosing spondylitis (an inflammatory disease where the bones of the ribs become less flexible and cause hard-to-deep breathing)
• non-radiographic axial spondyloarthritis (a type of arthritis in the spine) with objective signs of swelling.
• moderate to severe ulcerative colitis (inflammation in the part of the digestive system)

Dosage and Administration

Dosage and administration are different according to the disease and medical condition of the patients. You can not take Upacit XR by reading any sort of content on the internet. Do a proper physical examination, and the doctor will tell you whether you should take this medicine or not. There is general dosage information for Upacit XR as follows

• 15 mg daily to treat atopic dermatitis. The doctor may increase the dose up to 30 mg daily if adequate success is not achieved.
• 45 mg Upacit XR daily for 8 weeks to treat ulcerative colitis.
• 15 mg daily for ankylosing spondylitis.
• to treat non-radiographic axial spondyloarthritis, 15 mg daily.

Follow the instructions below to take Upacit XR

• Do not crush or chew the tablet; take it whole with a sufficient amount of water.
• Do not take the medicine immediately prior to or after taking food; wait until one or two hours before or after having meal to take the medicine. Otherwise, your body will not absorb the medicine properly.
• Instead of taking an adjustment dose, contact with doctor for any missed dose.
• For any other administration guidance, contact your doctor.
• Take the baricitinib tablet instant when you open it from the strip or bottle.

Possible side effects of Upacit XR 

Some serious side effects can occur because of Upacit XR, which can be difficult to tolerate for the patients.

• Upacit XR can weaken the strength of your immune system while you are taking this. It can reduce the ability to heal infections and other injuries during the treatment.
• Stomach pain may come along with diarrhea and constipation.
• Shortness of breath, tiredness may come during the treatment.

It can also cause other side effects like

• Nausea
• Headache
• Weakness
• Acne
• Red bumps around hair follicles

Ref(Medscape)

Take the below precautions before taking Upacit XR 

Precautions can make your treatment journey easy and smooth. It will make you aware of the bad things that can affect your treatment. Follow the below precautions before taking upadacitinib.

• Tell your doctor if you have any allergic conditions, as baricitinib can increase your allergies.
• If you have any serious medical condition where baricitinib can interact with other medications and create serious side effects.
• Ask your doctor which medicines and foods interact with Upadacitinib.
• Cancel your plan for the baby if you are going to take this medicine.
• Do not feed breast milk if you are going to take Upadacitinib.
• Inform your doctor if you have taken any antibiotics or other vitamins recently.
• Not all precautions are included here; please inform your healthcare provider of anything you think you should.
• Store the medicine in a dry place, away from direct sunlight and the reach of children.

Upacit XR Price in Bangladesh

The unit price of Upacit XR (generic upadacitinib) in Bangladesh is between $2-$2.5. Price is variable and can be changed depending on the manufacturer’s policy.

Is Upacit XR a biologic to the uapdacitinib?

Yes, Upacit XR is a biosimilar of upadacitinib. Each Upacit XR tablet contains 15 mg of the upadacitinib active ingredient. This biosimilar is manufactured and marketed by Incepta Pharmaceuticals Ltd..  

How much does upadacitinib cost in Bangladesh?

There are a few generic brands of Upadacitinib available in Bangladesh, which cost differently depending on the manufacturer. The cost should be higher for an established and trusted brand. Contact us for the exact brand price of Upadacitinib.

How effective is Upacit XR compared to other brands of Upadacitinib?

Upacit XR contains Upadacitinib 15 mg, a selective JAK-1 inhibitor used to treat rheumatoid arthritis, atopic dermatitis, and psoriatic arthritis. Its effectiveness is the same as other Upadacitinib brands, such as Rinvoq or Upacit XR, since all contain the same active ingredient. Clinical studies show Upadacitinib provides superior or comparable results to biologics like Adalimumab and Dupilumab in improving symptoms and disease control. Differences among brands mainly depend on manufacturing quality, not efficacy.