Buy Gilternib 40 mg online | Generic of Xospata (Gilteritinib)

Gilternib 40 mg (Generic Gilteritinib) – Informational Overview

Primary Indication:
Gilternib 40 mg (gilteritinib) is used for the treatment of adult patients with relapsed or refractory Acute Myeloid Leukemia (AML) who have a confirmed FLT3 mutation detected by an FDA-approved test.

Active Ingredient:
Gilteritinib

Dosage Strength:
40 mg film-coated tablets

Regulatory Status:
Gilteritinib is an FDA-approved FLT3 inhibitor. Gilternib 40 mg is a generic formulation containing the same active ingredient.

How Gilteritinib Works

Gilteritinib is a second-generation FLT3 inhibitor that selectively blocks abnormal FLT3 signaling pathways involved in the growth and survival of leukemia cells. By inhibiting these receptors it slows cancer cell proliferation and promotes apoptosis (cell death).
Its higher selectivity and potency compared to earlier FLT3 inhibitors contribute to improved outcomes in patients with FLT3-mutated AML.

Clinical Evidence

Clinical trials have shown that gilteritinib offers better response rates and overall survival compared with standard salvage chemotherapy in relapsed or refractory FLT3-mutated AML. It is considered a key targeted option for this patient population

Dosage and Administration

• Common Starting Dose: 120 mg orally once daily, continued until disease progression or unacceptable toxicity.

• Using 40 mg Tablets: The 40 mg strength allows for flexible, physician-guided dose adjustment (e.g., 120 mg = three tablets; 80 mg = two tablets).

• How to Take:
  • Take at the same time each day.
  • Can be taken with or without food.
  • Swallow tablets whole; do not chew or crush.

Monitoring and Safety Precautions

Patients receiving gilteritinib require regular monitoring, especially during the first two treatment cycles.

Key monitoring includes:

• Complete blood counts (CBCs)

• Electrocardiograms (ECGs) for the QTc interval

• Clinical assessment for signs of Differentiation Syndrome, which may require prompt treatment

Healthcare professionals may adjust the dose depending on tolerance, cardiac findings, or lab abnormalities.

Frequently Asked Questions (Informational Only)

Is Gilternib 40 mg the same as FDA-approved gilteritinib?

Gilternib contains the same active ingredient, gilteritinib, which is FDA-approved for treating FLT3-mutated relapsed or refractory AML. Generic versions should match the reference drug in quality and therapeutic effect according to regulatory standards.

How is gilteritinib usually accessed by patients?

Access depends on national regulations and medical practices. Typically, a physician’s prescription is required, followed by procurement through licensed pharmacies or authorized medical suppliers.

What should patients expect during treatment?

Patients should expect frequent follow-ups, lab tests, and monitoring for side effects such as fatigue, liver enzyme changes, QTc prolongation, or symptoms of Differentiation Syndrome. Any new or worsening symptoms should be reported promptly to a healthcare provider.

How much does Generic Gilteritinib cost in Bangladesh?

The per unit cost of generic Gilteritinib in Bangladesh will cost 12 USD. Price is variable and can be changed over the time.