Ponaxen-15/45mg-Ponatinib | Leukemia Targeted Therapy

What is Ponaxen (Ponatinib)?

Ponaxen-15/45mg-Ponatinib is an effective multi targeted cancer therapy. Doctor use this medication to treat chronic myeloid leukemia, Philadelphia chromosome positive acute lymphoblastic leukemia. This medication targets CML with the T315I mutation.

Ponatinib Mechanism of Action

Ponaxen targets BCR-ABL protein in the cancer cells and destroy them so that they do not signal the cancer cells to multiply in the blood. CML and philadelphia chromosom positive acute lymphoblastic leukemia, both produce the protein BCR-ABL. CML is a condition where BCR-ABL is responsible for the abnormal growth of white blood cells. In the both case, Ponaxen works like a multi targeted therapy and destroy the enzymes in the blood and helps patients to get cured.

Dosage and Administration

Ponaxen comes as 15 mg and 45 mg varients. The general dose for CML and ALK+ treatment is 45 mg Ponaxen every day at the same time. Dosage can be different according to the health condition of the patients and tolerability of the toxicity of the ponaxen. Doctors may adjust the dosage as follow or it can be different. For the better dosage modification contact with your doctor if you have any problems with the recommended dose.

Dosage adjustments

• Patients who have pre-existing hepatic impairment (Child-Pugh A, B, or C), adjust the dose at 30 mg ponaxen daily once.
• Patients who are taking strong CYP3A inhibitors, adjust the dose by 30 mg for once in a day.

• Different dosage adjustment may require for adverse reactions, such as blood clots, arterial occlusion, heart problems, and liver damage.

Dose reduction schedule

• First reduction: 30 mg PO q Day
• Second reduction: 15 mg PO q Day
• Third reduction: 10 mg PO q Day
• Unable to tolerate 10 mg/day: Permanently discontinue

Monitoring and Administration to use Ponaxen 15/45mg  Ponatinib

• Doctor may monitor the patients in schedule process for any kind of adverse reactions including, blood clots, arterial occlusion, heart problems, and liver damage.
• Complete blood count test might be necessary for the patients in every week for two months while taking ponaxen, then in every month after the completion of the dosage.
• Doctors also should check patients liver in every month for the first 3 months and at least once in every 3 months
• Patients have to swallow the whole tablet with a full glass of water or other liquid recommended by the docotr.
• Healthty and balanced life style of the patients can give extra advantages of the medicine and the fastest cure procedure.
• Do not take over dose or miss a dose. And do not adjust the missed dose with next scheduled dose.

For any other administration tips please contact with your doctor and health care provider. Do not take any decesion on your own, cause therapeutical medicine can react adversely.

Storage

Store the medicine at 15 to 30 degree celcius temperature for the better quality. Keep it away from children and direct sunlight. Do not freeze it or do not keep it in the over heated area.

Ponatinib Side Effects

Ponaxen-15/45mg-Ponatinib can cause some mild to severe side effects that can be harmful for the patients. Recognize the below mentioned side effects and notice if you face any of them while taking Ponaxen.

The most common side effects of Ponaxen include:

• Skin rash
• Joint pain
• Stomach ache
• Headache
• Constipation
• Blood pressure
• Shortness of breath
• Dry skin

Other side effects of Ponaxen include:

• Increased risk of infection
• Breathlessness and looking pale
• Bruising, bleeding gums, or nosebleeds

Ponaxen can also cause serious side effects, including:

• Blood clots: Ponaxen can clots blood to reduce the production of new abnormal cells. It can cause patients stroke, heart attack, and clots in the lungs.
• Arterial occlusion: In some cases ponaxen is responsible for narrowing the arteries that can cause serious problem.
• Heart problems: Because of interfaring in the blood production, heart might not get the enough blood flow and can cause heart failure or heart attack.
• Liver damage: Because of blood clots in the liver it can increase serious liver problems.

Ponatinib 45 mg price in Bangladesh

The price of Ponaxen 45 mg in Bangladesh is near about $450. But as the price is variable it can be changed. To get update price of ponxen 45 mg in 2025 contact with us.

Ponaxen 15 mg price in Bangladesh

Price of ponaxen 15 mg in Bangladesh is near about $250.

To order ponaxen 15mg and ponaxen 45mg tablet contact us through WhatsApp (+8801304498958), Facebook, Instagram.

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FAQ about Ponaxen-15/45mg-Ponatinib

How to use Ponaxen-15/45mg-Ponatinib?

Ponaxen-15/45mg-Ponatinib is an oral medicinethat comes in the fotabletswhichblet that means yotakee to taken it by mouth with or without f once in a day according to the prescription of your doctor.

What should I do if I miss doses of Pontinib ?

Contact immediately with your doctor if you miss a dose or several doses of Ponaxen.

What are the common side effects of Ponaxen-15/45mg-Ponatinib?

The common side effects of Ponatinib are bladder pain, cloudy urine, cough, coughing blood, decrease in urine output and so on.

How long can you take Ponatinib?

It actually depends on the condition of the patients or how their body react to the medicine. Normally doctors suggest to take Ponatinib untill it stop working or get too bad side effect.

Dose Ponatinib cause weight gains?

Contact your doctor if you face anything suspicious using this like rapid weight gain, decrease in the amount of urine .

Is ponatinib better than Dasatinib?

Research shows that in analysis in terms of using Ponatinib comparing to Dasatinib , Ponatinib is more effective than Dasatinib. It is more effective in blocking tumor cells than Dasatinib. We confirmed that ponatinib was more potent than dasatinib to induce apoptosis and inhibit proliferation of CML cells, in consensus with IPA and GO analysis results.

What class of drug is Ponatinib?

Ponatinib is a kinase Inhibitor. It works by blocking the action of an abnormal protein that signals cancer cells to multiply this helps stop the spread of cancer cells.

What generation is Ponatinib?

Ponaxen-15/45mg-Ponatinib is a third generation inhibitor for the patients who have CML.

Is Ponatinib approved for CML?

The approval of ponatinib for patients with chronic myeloid leukemia with resistance or intolerance of at least 2 prior kinase inhibitors, with appropriate monitoring and screening for AOE risk factors, provides another treatment option for patients with a poorer prognosis.