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Product Name: Baricinix-4mg

Generic Name: Baricitinib

Volume: 30 tablets

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Baricinix-4mg(Baricitinib) is a prescription medication used to treat rheumatoid arthritis, alopecia areata, and COVID-19 in adults who have not responded well to TNF inhibitors. It works by blocking the activity of Janus kinase (JAK) proteins, reducing inflammation, and improving symptoms, especially in those who require supplemental oxygen or ventilators. [1]

Baricinix-4mg(Baricitinib) is manufactured by the Bangladeshi Pharmaceutical BEACON which is a renowned pharmaceutical in Bangladesh. Baricinix-4mg is made under the brand name Olumiant and the generic name is Baricitinib.

Indication for using Baricinix-4mg(Baricitinib):

Baricitinib is a prescription medication used to treat the following specific conditions:

Rheumatoid arthritis (RA) in adults who have not responded well to one or more tumor necrosis factor (TNF) inhibitor medications. [2]

Alopecia Areata (AA) in adults with severe AA is defined as a Scalp Hair Loss Area Classification (SHLAC) score of ≥50%. [3]

Hospitalized adults with COVID-19 who require supplemental oxygen, a ventilator, or who need extracorporeal membrane oxygenation (ECMO).

Baricinix-4mg(Baricitinib) is a disease-modifying antirheumatic drug (DMARD) approved by the FDA for treating moderate to severely active rheumatoid arthritis in adults who have not responded well to other DMARDs. Clinical trials have shown significant improvement and inhibition of disease progression compared to placebo. In 2020, the FDA issued an emergency use authorization for baricitinib in combination with remdesivir for COVID-19 treatment in hospitalized patients. Baricitinib is not FDA-approved as a standalone treatment for COVID-19. Future trials, such as BREEZE-AD7, have shown baricitinib’s efficacy in improving the signs and symptoms of severe atopic dermatitis and alopecia areata. [4]

Mechanism of Action of  Baricinix-4mg(Baricitinib):

  • Baricinix-4mg(Baricitinib) is a Janus kinase (JAK) inhibitor that works by blocking the activity of JAKs, which can reduce inflammation and improve symptoms.
  • It inhibits the activity of JAK1 and JAK2, two of the four JAK proteins involved in the signaling pathways of pro-inflammatory cytokines. By inhibiting JAK1 and JAK2, baricitinib can block the signaling of these cytokines and reduce inflammation.
  • It also has other anti-inflammatory effects, such as reducing the production of inflammatory mediators and suppressing immune cell activation. Baricitinib has a higher affinity for JAK1 and JAK2, inhibiting JAK proteins, preventing phosphorylation and activation of STATs, and modulating the signaling pathway of various interleukins, interferons, and growth factors. It also decreases the proliferation of JAK1/JAK2 expression in mutated cells and induces cell apoptosis. [6]

Dosage and Administration:

Rheumatoid arthritis

The recommended dosage of baricitinib for rheumatoid arthritis is 2 mg once daily orally, with or without food.

Alopecia areata

The recommended dosage of baricitinib for alopecia areata is 2 mg once daily orally, with or without food. The dosage may be increased to 4 mg once daily if the response to treatment is not adequate.


The recommended dosage of baricitinib for COVID-19 is 4 mg once daily orally, with or without food, for 14 days or until hospital discharge, whichever occurs first.

Dosage adjustments

Dosage adjustments may be necessary for patients with certain conditions, such as kidney disease or liver disease. Dosage adjustments may also be necessary for patients who are taking certain medications that can interact with baricitinib.


Baricitinib is taken orally once daily. It is administrable with or without food. [7]

Side Effects:

Baricitinib’s common side effects include upper respiratory tract infections, headaches, nausea, diarrhea, fatigue, muscle pain, increased liver enzymes, cholesterol, and decreased white blood cell and platelet count. [8]


There are a few questions asked about Baricitinib-

What is Baricitinib-Baricinix-4mg?
Baricitinib, sold under the brand name Baricinix 4mg, is a medication used to treat certain inflammatory conditions, such as rheumatoid arthritis, in adults. It belongs to a class of drugs known as Janus kinase (JAK) inhibitors.
How does Baricitinib work in the body?
Baricitinib works by inhibiting specific enzymes called Janus kinases, which play a crucial role in the inflammatory response. By blocking these enzymes, Baricitinib helps reduce inflammation and alleviate the symptoms of conditions like rheumatoid arthritis.
What conditions are treated with Baricitinib-Baricinix-4mg?
Baricitinib (Baricinix 4mg) is primarily used to treat moderate to severe rheumatoid arthritis in adult patients who have not adequately responded to other disease-modifying antirheumatic drugs (DMARDs).
How should I take Baricitinib 4mg?
Baricitinib 4mg comes in tablet form and is usually taken orally once daily, with or without food. It is essential to follow your healthcare provider's instructions on how to take this medication.
Can I take Baricitinib with other arthritis medications?
The concomitant use of Baricitinib with certain other arthritis medications, such as biologic DMARDs or other JAK inhibitors, may not be recommended. It is crucial to inform your doctor about all medications you are taking to prevent potential drug interactions.
Are there any common side effects associated with Baricitinib (Baricinix 4mg)?
Yes, like any medication, Baricitinib may cause side effects. Common side effects may include upper respiratory tract infections, headache, nausea, and changes in blood test results. Contact your doctor if any side effects become bothersome or persistent.
Can pregnant or breastfeeding women take Baricitinib (Baricinix 4mg)?
Baricitinib may not be safe during pregnancy or while breastfeeding. It is essential to discuss your pregnancy status or plans with your doctor before starting this medication.
Is Baricitinib suitable for everyone with rheumatoid arthritis?
Baricitinib is not suitable for everyone with rheumatoid arthritis. Your doctor will evaluate your medical history and condition to determine if Baricitinib is the appropriate treatment for you.
Can Baricitinib be used for other conditions besides rheumatoid arthritis?
Currently, Baricitinib is FDA-approved for the treatment of rheumatoid arthritis only. It is essential to use this medication strictly as prescribed for the approved indications.
What should I do if I miss a dose of Baricitinib (Baricinix 4mg)?
If you miss a dose of Baricitinib, take it as soon as you remember on the same day. If it's almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for the missed one.
Can I consume alcohol while taking Baricitinib (Baricinix 4mg)?
While alcohol use with Baricitinib is generally not contraindicated, it is essential to consult your doctor regarding your alcohol consumption, especially if you have a history of liver problems.
Can Baricitinib 4mg be used in children or adolescents?
Baricitinib is not recommended for use in children or adolescents with rheumatoid arthritis, as its safety and effectiveness in pediatric populations have not been established.
How long will I need to take Baricitinib (Baricinix 4mg)?
The duration of Baricitinib treatment will depend on your response to the medication and your doctor's recommendations. It is essential to continue taking the medication as prescribed, even if you start feeling better.
Does Baricitinib increase the risk of infections?
Yes, Baricitinib may increase the risk of serious infections. It is crucial to promptly report any signs of infection to your doctor while on this medication.

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