304 North Cardinal St.
Dorchester Center, MA 02124
Generic Identity: Alectinib
Manufacturer: Everst Pharmaceutical ltd.
Quantity: 56 Tablets
Originator: Alecensa by Roche’s Chugai
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Alecnib(150mg)-Alectinib is used to treat a certain type of non-small-cell lung cancer (NSCLC) that has spread to other parts of the body. Alecnib(150mg) is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps slow or stop the spread of cancer cells.
Alecnib(150mg) is a second-generation oral drug used to treat non-small cell lung cancer by selectively inhibiting the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase, which causes cell proliferation. This prevents phosphorylation and reduces tumor cell viability.
Alecnib(150mg)-Alectinib is indicated for:
Alecnib(150mg)-Alectinib is a second-generation oral drug used to treat non-small cell lung cancer (NSCLC) by selectively inhibiting the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase. This prevents phosphorylation and activation of STAT3 and AKT, reducing tumor cell viability. Both Alecnib(150mg) and its metabolite M4 show similar activity against multiple mutant forms of ALK.
The most common side effects of Alecnib(150mg) include:
Less common but more serious side effects of Alecnib(150mg) include:
It is important to note that not everyone who takes Alecnib(150mg)-Alectinib will experience side effects, and the severity of side effects can vary from person to person. If you are taking Alecnib(150mg), be sure to talk to your doctor about the potential side effects and how to manage them.
Here are some additional things to keep in mind about Alectinib side effects:
The recommended dosage of Alectinib is 600 mg orally twice daily, with or without food. Alecnib(150mg)-Alectinib should be taken until disease progression or unacceptable toxicity.
The recommended dosage of Alecnib(150mg) in patients with severe hepatic impairment (Child-Pugh C) is 450 mg orally twice daily.
If a dose of Alecnib(150mg) is missed, the next dose should be taken as soon as possible. If vomiting occurs after taking a dose of Alectinib, the next dose should be taken at the scheduled time.
Alecnib(150mg) capsules should be swallowed whole with water. Do not open or dissolve the capsules. (5)
Price of the Alectinib varies country to country and also depends on manufacturer brand.
Alecnib(150mg) is manufactured in Bangladesh by Everest Pharmaceuticals is a renowned name in pharmaceutical industry. This medicine is available for everyone in the world contact with us to know the price because it changes with time.
Alectinib was approved by the FDA on December 11, 2015, for the treatment of patients with ALK-positive metastatic non-small cell lung cancer (NSCLC) whose disease has progressed on or who are intolerant of crizotinib.
On November 6, 2017, the FDA granted regular approval to alectinib for the treatment of patients with anaplastic lymphoma kinase (ALK)-positive metastatic NSCLC, as detected by an FDA-approved test.
The FDA’s approval of alectinib was based on the results of two clinical trials. In the first trial, alectinib was shown to be more effective than crizotinib in shrinking tumors and improving survival in patients with ALK-positive NSCLC whose disease had progressed on crizotinib. In the second trial, alectinib was shown to be effective in treating patients with ALK-positive NSCLC who were intolerant of crizotinib. (6)
Alecnib(150mg) treatment has shown significant improvements in life expectancy for patients with ALK-positive NSCLC. In the ALEX clinical trial, patients treated with Alecnib(150mg) had a median overall survival of 62.5 months, compared to 34.8 months in the crizotinib arm. The J-ALEX study also showed a significant improvement in OS for patients treated with Alecnib(150mg), with a median of 68.6 months. These results suggest that Alecnib(150mg) is an effective treatment for ALK-positive NSCLC, and patients treated with Alecnib(150mg) can expect to live longer than those treated with other therapies. (7)
Brigatinib and Alecnib(150mg) are both tyrosine kinase inhibitors (TKIs) that are used to treat ALK-positive non-small cell lung cancer (NSCLC). They are both effective in shrinking tumors and improving survival, but there are some key differences between the two drugs.
Brigatinib and Alecnib(150mg) both work by blocking the activity of the anaplastic lymphoma kinase (ALK) protein. ALK is a receptor tyrosine kinase that plays a role in cell growth and differentiation. When ALK is mutated or overexpressed, it can lead to uncontrolled cell growth and cancer.
Brigatinib is a more potent inhibitor of ALK than Alecnib(150mg). It also blocks the activity of other tyrosine kinases, such as ROS1 and MET, which can lead to additional benefits in some patients.
Brigatinib and Alecnib(150mg) are both effective in shrinking tumors and improving survival in patients with ALK-positive NSCLC. In the Phase III ALTA trial, brigatinib was shown to be more effective than alectinib in shrinking tumors in patients with ALK-positive NSCLC who had progressed on or were intolerant of crizotinib. The median progression-free survival (PFS) for patients in the brigatinib arm was 11.2 months, compared to 6.8 months for patients in the alectinib arm.
Compared to crizotinib, Alecnib(150mg) was shown in the Phase III ALEX trial to be more effective in shrinking tumors in patients with ALK-positive NSCLC who had not previously been treated with a TKI. The median PFS for patients in the Alecnib(150mg) arm was 12.5 months, compared to 7.2 months for patients in the crizotinib arm.
Both brigatinib and Alecnib(150mg) can cause side effects, the most common of which are fatigue, nausea, vomiting, diarrhea, and constipation. Brigatinib is more likely to cause interstitial lung disease (ILD) than Alecnib(150mg). (8)
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